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TRAM 39

CAS No. 197525-99-8

TRAM 39( 2-(2-chlorophenyl)-2,2-diphenylacetonitrile | 2-Chloro-alpha,alpha-diphenylbenzeneacetonitrile | TRAM-39 | ZINC27105797 )

Catalog No. M27729 CAS No. 197525-99-8

TRAM 39 is a selective blocker of intermediate-conductance Ca2+-activated K+channels.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TRAM 39
  • Note
    Research use only, not for human use.
  • Brief Description
    TRAM 39 is a selective blocker of intermediate-conductance Ca2+-activated K+channels.
  • Description
    TRAM 39 is a selective blocker of intermediate-conductance Ca2+-activated K+channels.(In Vitro):In coeliac neurons, TRAM 39 depressed the amplitude of the prolonged conductance underlying the slow afterhyperpolarization, (gKCa2) by 57%.
  • In Vitro
    TRAM-39 (1 μM) reduces the peak amplitude of gKCa2 in sympathetic LAH neurons (mean percentage change 56%) in BAE cells.TRAM-39 (200 nM) diminishes lipopolysaccharide (LPS)-induced cryptdin release from paneth cells.
  • In Vivo
    TRAM-39 (1 μM; adds to the perfusate) fully blocks all IKCa channels in multicellular preparations.
  • Synonyms
    2-(2-chlorophenyl)-2,2-diphenylacetonitrile | 2-Chloro-alpha,alpha-diphenylbenzeneacetonitrile | TRAM-39 | ZINC27105797
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    197525-99-8
  • Formula Weight
    303.79
  • Molecular Formula
    C20H14ClN
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (164.59 mM)
  • SMILES
    Clc1ccccc1C(C#N)(c1ccccc1)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chang W, et al. Pd-Catalyzed regioselective hydroesterification of 2-allylphenols to seven-membered lactones without external CO gas. Org Biomol Chem. 2016 Mar 21;14(11):3047-52.
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